Charles Thompson

Charles Thompson
Adjunct Professor of Medicinal Chemistry

Email: charles.thompson@umontana.edu

Phone: (406) 243-4643

At present, I hold an appointment as Full Professor of Medicinal Chemistry in the Department of Pharmaceutical Sciences and as Adjunct Professor in the Department of Chemistry at the University of Montana (UM). Prior to accepting a position at UM in 1994, I was a [tenured] Professor of Chemistry at Loyola University of Chicago (1985-1994) where many of my former graduate students earned their degrees. Much of my undergraduate teaching experience has been sophomore level organic chemistry. At the UG senior/graduate level, I instruct medicinal chemistry, heterocycles, bioorganic chemistry and advanced organic and organic synthesis.

 

Research Interests

Research in the Thompson Group falls into the category of bio-organic and medicinal chemistry. In most projects, our aim is study how organic molecules interact with biological systems. A majority of our work is in the area of neuroscience. Other projects include organic methodology and synthesis, RNA interactions and natural product isolation.

Representative Publications

“Identification of Butyrylcholinesterase Adducts after Inhibition with Isomalathion using Mass Spectrometry: Difference in Mechanism Between (1R)- and (1S)-Stereoisomers” Doorn, J.A.; Schall, M.; Gage, D.A.; Talley, T.T.; Thompson, C.M.; Richardson, R.J. Toxicol. Appl. Pharmacol. 2001, 176, 73-80.

“Examination of Cross-Antigenicity of Acetylcholinesterase and Butyrylcholinesterase using Anti-Acetylcholinesterase Antibodies,” George, K. M.; Montgomery, M.A.; Sandoval, L.E.; Thompson, C.M. Tox.Letters 2001, 126, 99-105.

“A Facile Route to Substituted Phosphorothionates Using Dimethyl Phosphite,” Trautmann, J.; Suarez, A.I.; Tongcharoensirikul, P.; Muth, G. W.; Thompson, C.M. Phosphorus Sulfur Silicon Relat. Elem. 2002, 177, 471-477.

“Synthesis and in Vitro Pharmacology of Substituted Quinoline-2,4-Dicarboxylic Acids as Inhibitors of Glutamate Vesicular Transport (VGLUT),” Carrigan, C.N.; Bartlett, R.D.; Esslinger, C.S.; Cybulski, K.A.; Tongcharoensirikul, P.; Bridges, R.J.; Thompson, C.M. J. Med. Chem. 2002, 45, 2260-2276.

“Synthesis and Preliminary Biological Evaluation of trans-3,4-Conformationally-Restricted Glutamate and Pyroglutamate Analogs as Novel EAAT2 Inhibitors,” Denton, T.D.; Seib, T.; Bridges, R.J.; Thompson, C.M. Bioorg. Med. Chem. Lett. 2002, 12, 3209-3213.

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