Ed Rosenberg

Edward Rosenberg
Professor

Email: ed.rosenberg@umontana.edu

Phone: (406) 243-2592

Lab: (406) 243-5133

Edward Rosenberg came to UM in August of 1993 from California State University, Northridge. He earned his Ph.D. from Cornell University in 1970 under the supervision of Professor J.J. Zuckerman. He carried out postdoctoral research under the directorship of Dr. E.W. Randall at Queen Mary College of the University of London and at the California Institute of Technology under the directorship of Professor J.D. Roberts. He has been Visiting Scientist at the University of Turin in Italy since 1974. Edward Rosenberg is an inorganic chemist with strong interests in organometallic compounds with biological activity and in the development of advanced materials for metal ion separations and recovery from acid mine leaches and drainages and industrial waste streams. He teaches undergraduate and graduate courses in inorganic and organometallic chemistry.

 

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Rosenberg Research Group

Research Interests

There are three current areas of research in the Rosenberg group. The first involves the design and development of new silica polyamine composite materials for applications in the mining industry and in metal ion remediation of industrial and acid mine drainage waste streams. This research involves synthesis, spectroscopic characterization and applications testing of new materials designed to be selective for a given metal or group of metal ions. This new technology is currently the basis for a new company, Purity Systems Inc.

The second area of research involves the development of new synthetic methods for functionalizing biologically important heterocycles using the unusual properties imparted to these molecules by binding them to a trinuclear metal cluster in special ways. This research involves organic and organometallic synthesis, extensive use of nuclear and electron magnetic resonance spectroscopies and the use of labeling experiments to understand reaction mechanism. The new pharmacophores produced are screened for biological activity through collaborations with the Pharmaceutical Sciences department at UM.

The third area of research involves the use water soluble metal clusters as biological markers for polynucleic acids and proteins. The aim of this research is to develop highly selective binding of metal clusters to bio macromolecules that can directly visualized by electron microscopy and used to gain phase information from X-ray diffraction experiments. Most recently, this work has led to the discovery that one these water soluble metal clusters inhibits telomerase, the enzyme that controls the metathesis of tumor cells. This discovery was featured in recent article in Chemical and Engineering News (Sept. 16, 2002, p 23). This work involves organic and organometallic synthesis, spectroscopic methods and the techniques of molecular biology. This work is being conducted in collaboration with research groups in the Piedmont Region of Italy.

Recently we have embarked on a new project involving the development of lifetime tunable metal based probes for studying the dynamics of biomacromolecules with time resolved, single molecule flourescence techniques.

Research Support: We gratefully acknowledge the support of the Montana Board of Research and Commercialization Technology and the National Science Foundation for support of this research.

Representative Publications

Garino, C., Ghiani, S. Gobetto, R., Nervis, C., Salassa, L., Rosenberg , E., Ross, J.B.A., Chu, X., Hardcastle, K. & Sabatini, C., (2007). Computational and spectroscoic studies of a ruutheneium terpyrudyl complex, Inorg. Chem., in press.

Bandosz, T., Seredych, M., Allen, J., Wood, J., and Rosenberg, E. (2007). Silica-polyamine based carbon composite absorbents as media for effective hydrogen sulfide absorption/oxidation, Chem of Materials, 19, 2500.

Sharmin, A., Minzaao, A., Salassa, L., Rosenberg, E., Ross, J.B.A., Kabir, S., Hardcastle, K. (2007). Synthesis, structure, photophysical and electrochemical behavior of 2-amino-ahtracene triosmium clusters, Inorg. Chim. Acta, in press.

Albertino, A., Garino, C., Ghiani, S., Gobetto, R., Nervi, C., Salassa, E., Rosenberg, E., Viscardi, G., Buscaino, R., Croce, G., Milanesio, M., and Sharnim A., (2007). Photophysical properties and computational investigations of Tricarbonyrhenium (I) [2-(4-methypyridin-2-yl) benzo-X-azole] L and tricarbonylrhenium (I) [4-methyl-2- (1-methyl-1H-benzo[d]-X-azol-2-yl) quinoline] L derivatives (X = N?CH3, O, or S; L=C1?, pyridine), J. Organometal Chem. 692, 1377.

Rosenberg, E., Hart, C., Hughes, M., Kailasam, R., Allen, J., Wood, J., Cross, B. (2007). Performance improvement through structural designa nd comparison with polystyrene resins of silica polyamine composites, Proceedings of the 67th International Water Conference, IWC-34.

Hughes, M. and Rosenberg E. (2007). Characterization and applications of poly-acetate modified silica polyamine composites. Sep. Sci. and Tech, 42, 261.

M. Hughes, D.Nielsen, E.Rosenberg, Roberto Gobetto,  A. Viale,S.D. Burton "Structural Investigations of Silica Polyamine Composites with Solid State NMR: Surface Coverage and Metal Ion Coordination, Ind. Eng. and Chem. Res. (2006) 45, 6538.

T. Nowroozi-Isfahani, D. G. Musaev, K.  Morokuma, E. Rosenberg "Computational Studies of  Nucleophilic Attack and Protonation of Electron-Deficient Benzoheterocycle Triosmium Clusters," Inorg. Chem. (2006) 45, 4963.

C. Garino, S. Ghiani, I. Bottero, R. Gobetto, C. Nervi, L. Salassa, E. Rosenberg, G. Caputo, G. Viscardi, I. Miletto, M. Milanesio "Synthesis, Electrochemical Luminescence and ECL Studies of Ruthenium (II) Bipyridyl and Heterocyclic Bidentate Ligands," Eur. Inorg. Chem. (2006) 14, 2839.

C. Garino, S. Ghiani, R. Gobetto, C. Nervi  L. Salassa, G. Croce, M. Milanesio, E.Rosenberg, J. B. A. Ross             "Tricarbonylchlororhenium (I) carboxaldimine derivatives: synthesis, structure and NMR characterization of Z and E isomers," Eur. Inorg. Chem. (2006) 14, 2885.

S. E. Kabir, M. A. Mottalieb, G. M. G. Hossain, E. Nordlander, E. Rosenberg "Reactions of  (?-H)Os3(CO)10(OMe) and of  (?-H)Os3(CO)9(OMe)(MeCN) with dppm, dppe, dppp and PPh2H," Polyhedron (2006) 25, 95.

S. E. Kabir, M. S. Saha, D. A. Tocher, G. M. G. Hossain, E. Rosenberg "Triosmium Clusters Containing  dppm and EPh,"  J .Organometal. Chem.  (2006) 691, 97.

M. Hughes and E. Rosenberg "Characterization and Applications of Poly-Acetate Modified Silica    Polyamine Composites," Sep. Sci. and Tech.42 (2007) 261.

A. Albertino, C. Garino,  S. Ghiani, R. Gobetto, C. Nervi, L. Salassa, E. Rosenberg, G. Viscardi, R. Buscaino, G. Croce,  M. Milanesio, A. Sharmin "Photophysical Properties and Computational  Investigations of Tricarbonylrhenium(I)[2-(4-methylpyridin-2-yl)benzo-X-azole]L and Tricarbonylrhenium(I)[4-methyl-2-(1-methyl-1H-benzo[d]-X-azol-2-yl)quinoline]Lderivatives (X = N?CH3, O, or S; L = Cl?, pyridine), J. Organometal Chem 692 .(2007) 1377.

Kurt E. Geckeler and E. Rosenberg, "Functional Nanomaterials," American Scientific Publishers, Stevenson Ranch, CA,   2006

M. Hughes, Paul Miranda, D. Nielsen, E. Rosenberg, R. Gobetto, A.Viale, S. Burton "Silica polyamine composites: new supramolecular materials for cation and anion recovery and remediation," in Recent Advances and Novel Approaches in Macromolecule-Metal Complexes, Eds., R Barabucci, (F. Ciardelli, G. Ruggeri) Wiley-VCH (Macromolecular Symposia 235), Weinheim, 2006, p 161.

M. Hughes, D. Nielsen, E. Rosenberg, Roberto Gobetto, S. Viale, S.D. Burton "Structural Investigations of Silica Polyamine Composites with Solid State NMR: Surface coverage and Metal Ion Coordination, Ind. Eng. and Chem. Res. (2006) in press.

T. Nowroozi-Isfahani, D.G. Musaev, K. Morokuma, E. Rosenberg "Computational Studes of Nucleophilic Attack and Protanation of Electron-Deficient Benzoherterocycle Triosmium Clusters." Inorg. Chem. (2006) 45, 4963.

C. Garina, S.Ghiani, I. Bottero, R. Gobetto, C. Nervi, L Salassa, E. Rosenberg, G. Caputo, G Viscardi, I. Miletto, M. Milanesio "Synthesis, Electrochemical Luminescence and ECL Studies of Ethenium (II) Bipyridyl and Hetricyclic Bidentate Ligants," Euro. Inorg. Chem (2006) 14 2839.

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