ON SABBATICAL DURING THE 2007-2008 SCHOOL YEAR

Kent Sugden

Kent Sugden
Associate Professor

Email: kent.sugden@umontana.edu

Phone: (406) 243-4193

Lab: (406) 243-4046

Kent Sugden received his Ph.D. in chemistry from Montana State University in 1992. He was an NIH postdoctoral research fellow at Dartmouth College from 1993-95, a research associate at Dartmouth College from 1995-97 and a research assistant professor at Dartmouth from 1997-99. Kent joined the University of Montana chemistry department in June of 1999 where he conducts research in bioinorganic chemistry when not wrestling freshwater sharks on the Missouri River.

 

Course Links

Links of Interest

Research Interests

My research focuses on the mechanism of interaction of metal complexes with biomolecules that can lead to the formation of genetic aberrations such as mutations, cancer and toxicity. My primary metal of interest is chromium, which in the +6 oxidation state, is a known human carcinogen. One method by which chromium may induce cancer in humans is through oxidative damage to nucleic acids. Our research group is focused on the mechanism by which this oxidative chemistry may occur and the resulting lesions that are formed on DNA that can give rise to carcinogenesis.

Other active research areas being pursued in our research group include chromium-DNA binding modes, chromium-RNA interactions and mineral metabolism.

Representative Publications

Martin, B.D., Schoenhard, J.A., Hwang, J-M., and Sugden, K.D. 2006 “Ascorbate is a Pro-oxidant in Chromium-Treated Human Lung Cells.  Mutation Research. 610, 76-84.

Hailer, M.K., Slade, P.G., Martin, B.D., and Sugden, K.D. 2005 “Nei-deficient Escherichia coli are differentially sensitized to chromate through the accumulation of the oxidized guanine lesion spiroiminodihydantoin” Chem. Res. Toxicol. 18, 1378-1383.

Slade, P.G., Hailer, M.K., Martin, B.D. and Sugden, K.D. (2005) “Guanine-specific oxidation of double-stranded DNA by Cr(VI) and ascorbic acid forms spiroiminodihydantoin and 8-oxo-2'-deoxyguanosine” Chem. Res. Toxicol. 18, 1140-1149.

Hailer M. K., Slade, P. G., Martin, B.D., Rosenquist, T.E., and Sugden, K.D. (2005) “Recognition of the Oxidized Lesions Spiroiminodihydantoin and Guanidinohydantoin in DNA by the Mammalian Base Excision Repair Glycosylases NEIL1 and NEIL2” DNA Repair, 4, 41-50.

Sugden, K.D., Rigby, K.M., and Martin, B.D. (2004) “Oxidative activation of the human carcinogen chromate by arsenite: A model for synergistic metal activation leading to oxidative DNA damage”. Toxicology In Vitro, 18, 741-748.

Hailer-Morrison, M.K., Kotler, J.M., Martin, B.D., and Sugden, K.D. (2003) “Oxidized Guanine Lesions as Modulators of Gene Transcription. Altered p50 Binding Affinity and Repair Shielding by 7,8-dihydro-8-oxo-2'-deoxyguanosine Lesions in the NF-kB Promoter Element” Biochemistry, 42: 9761-9770.

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