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Biophysics and Structural Biology

Faculty Program Interests

 

Bruce Bowler

Bruce Bowler

Professor

bruce.bowler@umontana.edu

Biochemistry & Biophysics

Chemistry

Protein folding, conformationally-gated electron transfer and structural biology of cytochromes.

 

Klara Briknarova

Klára Briknarová

Associate Professor

klara.briknarova@umontana.edu

Biochemistry & Biophysics

Chemistry

Nuclear magnetic resonance (NMR) spectroscopy, biochemical and biophysical techniques to study the structure, function and dynamics of biological macromolecules.

Kasper Hansen

Kasper Hansen

Assistant Professor

kasper.hansen@umontana.edu

Biomedical Sciences

Neuroscience

Studies on the structure, function, and molecular pharmacology of ligand-gated ion channels using a multidisciplinary approach (electrophysiology, synthetic biology, molecular screening, biochemistry, structural biology, and molecular modeling). Evaluation of ionotropic glutamate receptors in synaptic transmission, neuronal signaling, and synaptic plasticity, as well as their involvement in psychiatric and neurological disorders.

 

Bradley Layton

Bradley Layton

Associate Professor

bradley.layton@umontana.edu

Biochemistry & Biophysics

Nanoscale biomechanics; drought resistance mechanisms; anthropogenic entropy acceleration.

 

Michele McGuirl

Michele McGuirl

Professor

michele.mcguirl@umontana.edu

Cellular, Molecular & Microbial Biology

Biochemistry & Biophysics

Prion protein aggregation and electron transfer through tyrosyl radicals.

 

Sandy Ross

J.B. Alexander (Sandy) Ross

Professor

sandy.ross@umontana.edu

Biochemistry & Biophysics

Chemistry

Use of ensemble-average and single-molecule fluorescence to investigate the relationship between biological function and structural dynamics in protein-protein and protein-membrane interactions.

 

Steve Sprang

Stephen R. Sprang

Professor

stephen.sprang@umontana.edu

Cellular, Molecular & Microbial Biology

Biochemistry & Biophysics

Structural and biophysical mechanisms in signal transduction.

Recent publications related to Biophysics and Structural Biology from UM Faculty:

A cytochrome C electron transfer switch modulated by heme ligation and isomerization of a peptidyl-prolyl bond. Bandi S, Bowler BE. Biopolymers. 2013 Apr;100(1):114-24. doi: 10.1002/bip.22164. PMID: 23335173

Dissociation of recombinant prion protein fibrils into short protofilaments: implications for the endocytic pathway and involvement of the N-terminal domain. Qi X, Moore RA, McGuirl MA. Biochemistry. 2012 Jun 5;51(22):4600-8. Epub 2012 May 23. PMID: 22591453

Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits. Chan P, Thomas CJ, Sprang SR, Tall GG. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3794-9. doi: 10.1073/pnas.1220943110. Epub 2013 Feb 19. PMID: 23431197

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