Institutional Animal Care & Use Committee (IACUC)
Institutional Animal Care & Use Committee (IACUC)
NOTICE OF DISCLAIMER: The information provided above is not intended to serve as a substitute for informed medical advice. If you use any of the anesthetic tranquilizers, sedatives, anesthetics, or pain medications included in this table, seek expert advice prior to using. The University of Montana disclaims all liability arising from the misuse of this information or the reliance on this information by any lay person, veterinarian, or non-UM entity.
Note: Most injectable drugs may be given subcutaneously (SC) in healthy mice, rats, guinea pigs, rabbits, and sheep. Onset of action may be slightly longer than IM or IP. Do NOT give ketamine IM in guinea pigs.
|
Drugs(s) |
Mouse |
Rat |
Guinea Pig |
Rabbit |
|
Acepromazine |
1-3 mg/kg IM, IP |
1-3 mg/kg IM, IP |
2-5 mg/kg IM, IP |
1-5 mg/kg IM |
|
Buprenorphine |
0.05-0.1 mg/kg SC Q6-12 hrs |
0.01-0.25 mg/kg SC Q6-12 hrs |
0.05-1 mg/kg SC Q6-12 hrs |
0.01-0.1 mg/kg SC Q8-12 hrs |
|
Diazepam |
5 mg/kg IP |
2-4 mg/kg IP, IM |
2.5-5 mg/kg IM, IP |
4-10 mg/kg IM |
|
Ketamine (rarely used alone) |
50-200 IM, IP |
50-100 mg/kg IM, IP |
50-200 mg/kg SC |
40-50 mg/kg IM |
|
Ketamine & Xylazine |
90-120 mg/kg & 8-12 mg/kg IM, IP |
40-90 mg/kg & 5-10 mg/kg IM, IP |
40-50 mg/kg & 5 mg/kg SC, IP |
35-50 mg/kg & 5-10 mg/kg IM |
|
Lidocaine or Bupivacaine (local analgesia) |
2-3 mg/kg SC or dripped in incision; diluted 1:10 |
2-3 mg/kg SC or dripped in incision; diluted 1:10 |
2-3 mg/kg SC or dripped in incision; diluted 1:10 |
2-3 mg/kg SC or dripped in incision; diluted 1:10 |
|
Pentobarbital 390 mg/ml [Beuthanasia or Euthasol (for euthanasia)] |
150 mg/kg IP |
150 mg/kg IP |
150 mg/kg IP |
> 1 ml per 10 lbs IV |
|
Propofol |
7.5-15 mg/kg IV |
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|
Xylazine |
4-12 mg/kg IM, IP |
1-10 mg-kg IM, IP |
3-5 mg/kg IM, SC |
1-5 mg/kg IM |
|
Drugs(s) |
Sheep |
Zebrafish |
Xenopus |
Bird |
|
Acepromazine |
0.05-5 mg/kg IM |
0.5-1 mg/kg IM |
||
|
Buprenorphine |
0.005-0.01 mg/kg IM Q6 hrs |
0.01-0.05 mg/kg IM |
||
|
Diazepam |
0.5-1.5 mg/kg IM |
0.5-1 mg/kg IM Q8-12 hrs |
||
|
Ketamine (rarely used alone) |
20-45 mg/kg IM 1 mg/kg IV before propofol |
|||
|
10-50 mg/kg IM |
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|
Ketamine & Xylazine |
5-50 mg/kg & 1-10 mg/kg IM |
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|
Lidocaine or Bupivacaine (local analgesia) |
2-3 mg/kg SC or dripped in incision; diluted 1:10 |
1 mg/kg SC or dripped in incision; diluted 1:10 |
||
|
Pentobarbital 390 mg/ml [Beuthanasia or Euthasol (for euthanasia)] |
> 1 ml per 10 lbs IV |
100 mg/kg IV |
||
|
Propofol |
4-6 mg/kg IV |
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|
Tricaine methane sulfonate (MS-222) |
25-100 mg/L buffered with NaHCO3 |
500-2000 mg/L bath buffered with NaHCO3 |
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|
Xylazine |
0.05-1 mg/kg IM |
Use with ketamine |
Animal Care and Use Committee
The University of Montana
Kathryn Mariucci, 406-243-6395
IACUC Coordinator, Biosafety Officer