Laboratory Animal Resources

Standard Operating Procedures

University of Montana LAR Anesthetic Dosage Table

Last updated: March 12, 2012

NOTICE OF DISCLAIMER: The information provided above is not intended to serve as a substitute for informed medical advice. If you use any of the anesthetic tranquilizers, sedatives, anesthetics, or pain medications included in this table, seek expert advice prior to using. The University of Montana disclaims all liability arising from the misuse of this information or the reliance on this information by any lay person, veterinarian, or non-UM entity.

Note: Most injectable drugs may be given subcutaneously (SC) in healthy mice, rats, guinea pigs, rabbits, and sheep. Onset of action may be slightly longer than IM or IP. Do NOT give ketamine IM in guinea pigs.

Drugs(s)	Mouse	Rat	Guinea Pig	Rabbit
Acepromazine	1-3 mg/kg IM, IP	1-3 mg/kg IM, IP	2-5 mg/kg IM, IP	1-5 mg/kg IM
Buprenorphine	0.05-0.1 mg/kg SC Q6-12 hrs	0.01-0.25 mg/kg SC Q6-12 hrs	0.05-1 mg/kg SC Q6-12 hrs	0.01-0.1 mg/kg SC Q8-12 hrs
Diazepam	5 mg/kg IP	2-4 mg/kg IP, IM	2.5-5 mg/kg IM, IP	4-10 mg/kg IM
Ketamine (rarely used alone)	50-200 IM, IP	50-100 mg/kg IM, IP	50-200 mg/kg SC	40-50 mg/kg IM
Ketamine & Xylazine	90-120 mg/kg & 8-12 mg/kg IM, IP	40-90 mg/kg & 5-10 mg/kg IM, IP	40-50 mg/kg & 5 mg/kg SC, IP	35-50 mg/kg & 5-10 mg/kg IM
Lidocaine or Bupivacaine (local analgesia)	2-3 mg/kg SC or dripped in incision; diluted 1:10	2-3 mg/kg SC or dripped in incision; diluted 1:10	2-3 mg/kg SC or dripped in incision; diluted 1:10	2-3 mg/kg SC or dripped in incision; diluted 1:10
Pentobarbital 390 mg/ml [Beuthanasia or Euthasol (for euthanasia)]	150 mg/kg IP	150 mg/kg IP	150 mg/kg IP	150 mg/kg IV
Propofol				7.5-15 mg/kg IV
Xylazine	4-12 mg/kg IM, IP	1-10 mg-kg IM, IP	3-5 mg/kg IM, SC	1-5 mg/kg IM

Drugs(s)	Sheep	Zebrafish	Xenopus	Bird
Acepromazine	0.05-5 mg/kg IM			0.5-1 mg/kg IM
Buprenorphine	0.005-0.01 mg/kg IM Q6 hrs			0.01-0.05 mg/kg IM
Diazepam	0.5-1.5 mg/kg IM			0.5-1 mg/kg IM Q8-12 hrs
Ketamine (rarely used alone)	20-45 mg/kg IM 1 mg/kg IV before propofol			10-50 mg/kg IM
Ketamine & Xylazine				5-50 mg/kg & 1-10 mg/kg IM
Lidocaine or Bupivacaine (local analgesia)	2-3 mg/kg SC or dripped in incision; diluted 1:10			1 mg/kg SC or dripped in incision; diluted 1:10
Pentobarbital 390 mg/ml [Beuthanasia or Euthasol (for euthanasia)]	> 1 ml per 10 lbs IV			100 mg/kg IV
Propofol	4-6 mg/kg IV
Tricaine methane sulfonate (MS-222)		25-100 mg/L buffered with NaHCO3	500-2000 mg/L bath buffered with NaHCO3
Xylazine	0.05-1 mg/kg IM			Use with ketamine

Laboratory Animal Resources

The University of Montana

Kelly Carrick, rLATG, ILAM

Facility Manager

Phone: 406-243-4892